Innovations in translational medical imaging devices to better diagnose cancers, low-cost point-of-care diagnostic tools to delivery life-saving medicines to the resource-poor regions, and high performance computing tools to facilitate the development of the next-generation imaging methods
Our long-term research goal is to develop and apply innovative spatial, single cell and optical technologies that will transform our understanding of cellular communication in health and disease and use this insight to develop new treatments.
Entrepreneurship education microenvironments and their impact on the engagement of diverse populations, the influence of I-Corps on university ecosystems, and transforming BME education through instructional design
Physical modeling of cancer progression, metastasis and interaction with the immune system. Most recent interests include the role of metabolic plasticity in these processes and the co-evolution of the tumor and the adaptive immune system. Other areas include spatial organization of the actin cytoskeleton, the mechanics of collective cell motility, and the analysis of genetic circuits involved in cell fate decisions.
Computational systems biology, an integration of mathematical modeling and bioinformatics for studying gene regulatory networks, single cell genomics, epithelial-mesenchymal transition, coarse-graining, reverse engineering, machine learning, stochasticity and heterogeneity in gene expression
Developing chemical approaches to track and quantify important RNA processing events and modifications in single cells; DNA: protein interactions that drive differences in gene expression; understanding differences in RNA expression and the impacts on disease and development
Cellular and molecular mechanomedicine, Cancer cell biology and mechanics, Embryonic stem cell biology and mechanics, Mechanical biotechnologies and their applications to cells, tissues, and organisms, Mechanotransduction: nuclear deformation and gene expression
development of next-generation DNA and RNA sequencing methods; nanopores as molecular sensors; bioinspired sustainability solutions; optical and electrical analysis of biomolecular systems; electron microscopy and electron-beam shaping of nanomaterials