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Molecular, Cell and Tissue Engineering

various microscope images of cell and tissue

Analysis of the LacNAc level on a lung adenocarcinoma microarray. Source: Prof. Sara Rouhanifard

Principles for engineering living cells and tissues are essential to address many of the most significant biomedical challenges facing our society today. These application areas include engineering biomaterials to coax and enable stem cells to form functional tissue or to heal damaged tissue; designing vehicles for delivering genes and therapeutics to reach specific target cells to treat a disease; and uncovering therapeutic strategies to curb pathological cell behaviors and tissue phenotypes. At a more fundamental level, the field is at the nascent stages of understanding how cells make decisions in complex microenvironments and how cells interact with each other and their surrounding environment to organize into complex three-dimensional tissues. Advances will require multiscale experimental, computational, and theoretical approaches spanning molecular-cellular-tissue levels and integration of molecular and physical mechanisms, including the role of mechanical forces.