Biomechanics and Mechanobiology

Motion, deformation, and flow of biological systems in response to applied loads elicit biological responses at the molecular and cellular levels that support the physiological function of tissues and organs and drive their adaptation and remodeling. To study these complex interactions, principles of solid, fluid, and transport mechanics must be combined with measures of biological function. The Biomechanics and Mechanobiology research area embraces this approach and leverages the strong expertise of Northeastern faculty attempting to tie applied loads to biological responses at multiple length and time scales.

Primary faculty contacts


Rouzbeh Amini
Associate Professor,  Mechanical and Industrial Engineering & Bioengineering
Associate Professor,  Bioengineering

Biomechanics, mechanobiology, biotransport


Chiara Bellini
Chiara Bellini
Associate Professor and Associate Chair for Graduate Studies,  Bioengineering

Diseases of the cardiovascular system; effects of cellmediated growth and remodeling processes on tissue and organ mechanics


Guohao Dai
Guohao Dai
Professor,  Bioengineering

3-D bioprinting technology, stem cells technology and vascular bioengineering


Daniel Grindle
Daniel Grindle
Assistant Teaching Professor,  Bioengineering


Jessica Oakes
Jessica Oakes
Associate Professor,  Bioengineering

Pulmonary physiology, biofluids and transport phenomenon, computational biomechanics, magnetic resonance imaging, multi-scale modeling


Harikrishnan Parameswaran
Harikrishnan Parameswaran
Associate Professor,  Bioengineering

We study cell-cell and cell-extracellular matrix interactions in the airway to understand the fundamental mechanisms that regulate airway caliber and why they fail in diseases like asthma.


Jeffrey W. Ruberti
Jeffrey W. Ruberti
Professor,  Bioengineering
Affiliated Faculty,  Mechanical and Industrial Engineering

Tissue engineering of load-bearing matrix (bone, cornea); bioreactor design; multi-scale mechanobiochemistry; statistical mechanics; energetics microscopy; high-resolution imaging; biopolymer self-assembly


Sandra Shefelbine
Sandra Shefelbine
Associate Dean for Space and Special Initiatives,  Office of the Dean
Professor,  Mechanical and Industrial Engineering & Bioengineering
Professor,  Bioengineering

Multi-scale bone biomechanics–how the structure and composition of bone influences its mechanical properties; mechano-adaptation of bone and joint– how tissue responds to mechanical signals


Tao Sun
Tao Sun
Assistant Professor,  Bioengineering

Focused Ultrasound, Ultrasound Imaging, Neuroimaging, Drug Delivery, Immunomodulation and Immunoengineering, Gliomblastoma, Alzheimer’s Disease


Amir Vahabikashi
Amir Vahabikashi
Assistant Professor,  Bioengineering

Cell and nucleus mechanobiology, soft bioelectronics for organoid/tissue scale mechanobiology and regenerative engineering, mechanotransduction, implantable bioelectronics


Ning Wang
Ning Wang
Professor,  Bioengineering
Director,  Institute for Mechanobiology

Cellular and molecular mechanobiology, mechanomedicine, and mechanohealth; cancer cell biology and mechanics; stem cell biology and mechanics; mechanomemory and mechanoresilience, mechanobiotechnologies and their applications to cells, tissues, and organisms