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We study cell-cell and cell-extracellular matrix interactions in the airway to understand the fundamental mechanisms that regulate airway caliber and why they fail in diseases like asthma.
Developing chemical approaches to track and quantify important RNA processing events and modifications in single cells; DNA: protein interactions that drive differences in gene expression; understanding differences in RNA expression and the impacts on disease and development
Multi-scale bone biomechanics–how the structure and composition of bone influences its mechanical properties; mechano-adaptation of bone and joint– how tissue responds to mechanical signals
Motor control and learning, variability and stability, virtual rehabilitation, dynamic modeling, rhythmic and discrete movements as primitives for action
Cellular and molecular mechanobiology, mechanomedicine, and mechanohealth; cancer cell biology and mechanics; stem cell biology and mechanics; mechanomemory and mechanoresilience, mechanobiotechnologies and their applications to cells, tissues, and organisms
Our group investigates biomolecules at the single-molecule level. We develop nanopore-based and other nanotechnology-based methods for probing the structure and dynamic behavior of biomolecules. We employ optical waveguides and single-molecule enzymatic approaches for RNA sequencing, and utilize engineered nanopore sensors for applications in single-molecule proteomics. We are experimentalists, but we also use advanced computational tools to perform big data analysis.
dynamics of large-scale molecular machines, working to identify the physical principles that guide biomolecular dynamics, using molecular simulation approaches to interpret experimental data from a wide range of techniques, including biochemical, small-angle X-ray scattering and cryogenic electron microscopy